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[Misc] Weight loss jabs - Mounjaro, Wegovy etc.



The Clamp

The Clamp

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Jan 11, 2016
26,182
West is BEST
Mounjaro comes with an FDA “black box” warning that the drug has caused both cancerous and non-cancerous thyroid tumors in mice and rats. The higher the dose and the longer they were on the medication, the higher the risk for tumors.

It’s not yet known whether the medication might have the same effect on people, but it isn’t recommended for people who have a personal or family history of thyroid cancer.
If you’re taking Mounjaro, and you have any of the following symptoms, tell your doctor:
  • A lump or swelling in your neck
  • Hoarseness
  • Trouble swallowing
  • Shortness of breath
These were the FDA findings published on Med Web on 12th July 2024.


And for that reason , I’m out.



It’s a drug for treating diabetes and as such it’s got the potential to cause havoc for those with normal blood sugars.

I don’t think it’s safe and I don’t think it works.

It’s not been used or tested for a long enough time period for me to feel it is safe or effective.
 




Weststander

Weststander

Well-known member
Aug 25, 2011
69,241
Withdean area
The Clamp said:
Yes, I’ve read about the starvation theories.

I don’t buy them. Purely because it’s not sustainable.


Diet is important. Cut out processed crap. Refined sugars. Eat more fibre. Limit your meat intake. Get calories from real food. Eat a fair bit of fruit and a lot of veg.

Treat yourself now and again.

Stay mobile.

Approx 75-80% of older people in care homes are there for no other reason than they have limited mobility. Can’t get out of bed or a chair unassisted.

Any weight loss will result in lower cholesterol, lower blood pressure, and a healthier heart.

It’s unlikely to be the drugs that are doing that , it’s a natural result of weight loss. Arguably, that’s down to the drug. But you’ll get those benefits with natural weight loss. And it’ll be healthier.


Look, if these meds work and somebody needs to clinically reduce BP or cholesterol then okay, I get it. But I don’t think it’s sustainable. Quick fixes don’t last long.
Click to expand...

If you ever have time, listen to the Mosley inflammation doc on R4. He let world leading experts do the talking, fasting works. It takes us back to our natural state of the next meal not always being around. Our organs, metabolism, immune system get a natural rest and reset.

Once at a good weight, the experts themselves still fast a little to keep getting the benefits.

It goes against human physiology to sauce ample food every time you feel slightly ‘hungry”.
 


The Clamp

The Clamp

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NSC Patron
Jan 11, 2016
26,182
West is BEST
Weststander said:
If you ever have time, listen to the Mosley inflammation doc on R4. He let world leading experts do the talking, fasting works. It takes us back to our natural state of the next meal not always being around. Our organs, metabolism, immune system get a natural rest and reset.

Once at a good weight, the experts themselves still fast a little to keep getting the benefits.

It goes against human physiology to sauce ample food every time you feel slightly ‘hungry”.
Click to expand...
I will certainly look into it, thanks.
 




The Clamp

The Clamp

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Jan 11, 2016
26,182
West is BEST
When I look at the food young people eat these days and the frequency and ease with which they order takeaway food, I fear we are heading towards a diabetes and heart disease epidemic within 15-20 years.
 




Albion my Albion

Albion my Albion

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Feb 6, 2016
19,609
Indiana, USA
The Clamp said:
When I look at the food young people eat these days and the frequency and ease with which they order takeaway food, I fear we are heading towards a diabetes and heart disease epidemic within 15-20 years.
Click to expand...

I would say in the US it has already happened. Although after the jabs were introduced food companies started to complain there was a downturn in snack eating the the US. They actually started lobbying the government officials to do something to prevent this. Trump OTOH is doing everything he can to help the snack providers. Look at his body shape!
 


P

Professor Plum

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Jul 27, 2024
607
The Clamp said:
Mounjaro comes with an FDA “black box” warning that the drug has caused both cancerous and non-cancerous thyroid tumors in mice and rats. The higher the dose and the longer they were on the medication, the higher the risk for tumors.

It’s not yet known whether the medication might have the same effect on people, but it isn’t recommended for people who have a personal or family history of thyroid cancer.
If you’re taking Mounjaro, and you have any of the following symptoms, tell your doctor:
  • A lump or swelling in your neck
  • Hoarseness
  • Trouble swallowing
  • Shortness of breath
These were the FDA findings published on Med Web on 12th July 2024.


And for that reason , I’m out.



It’s a drug for treating diabetes and as such it’s got the potential to cause havoc for those with normal blood sugars.

I don’t think it’s safe and I don’t think it works.

It’s not been used or tested for a long enough time period for me to feel it is safe or effective.
Click to expand...
This class of drugs, and the way they work, have been passed as safe by both the NHS and FDA.

People with a family history of thyroid cancer, and no doubt other conditions, are weeded out at the GP stage. They won't be prescribed. There are plenty of warnings aimed at particular groups.

These are now mainstream treatments. But it's right to point out that certain people shouldn't take them.
 


Weststander

Weststander

Well-known member
Aug 25, 2011
69,241
Withdean area
The Clamp said:
When I look at the food young people eat these days and the frequency and ease with which they order takeaway food, I fear we are heading towards a diabetes and heart disease epidemic within 15-20 years.
Click to expand...

Including the drinks. It was Red Bull, now also Monster, cans of the stuff per day sometimes. The supermarkets have very well merchandised Monster coolers. I know younguns who get over being awake half the night, for uni lectures, by downing a can of Monster.

I think the epidemic is here already, we’ve followed the Yanks.

Best not mention vaping too :eek:.
 




P

Professor Plum

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Jul 27, 2024
607
The Clamp said:
When I look at the food young people eat these days and the frequency and ease with which they order takeaway food, I fear we are heading towards a diabetes and heart disease epidemic within 15-20 years.
Click to expand...
It's hard to generalise. There's not really any such thing as 'young people' as a class. I keep reading that young people don't drink and go to bed at 9pm. I'm sure plenty do but certainly plenty don't from what I can see!
 


P

Professor Plum

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Weststander said:
Including the drinks. It was Red Bull, now also Monster, cans of the stuff per day sometimes. The supermarkets have very well merchandised Monster coolers. I know younguns who get over being awake half the night, for uni lectures, by downing a can of Monster.

I think the epidemic is here already, we’ve followed the Yanks.

Best not mention vaping too :eek:.
Click to expand...
Monster must be spending a fortune on marketing. I'm sure you've noticed that Fabian Hürzeler sits in front of 2 cans of the stuff at every single press conference.
 


Weststander

Weststander

Well-known member
Aug 25, 2011
69,241
Withdean area
Professor Plum said:
This class of drugs, and the way they work, have been passed as safe by both the NHS and FDA.

People with a family history of thyroid cancer, and no doubt other conditions, are weeded out at the GP stage. They won't be prescribed. There are plenty of warnings aimed at particular groups.

These are now mainstream treatments. But it's right to point out that certain people shouldn't take them.
Click to expand...

If someone (not to suggest you) is say 5st overweight and type 2 diabetes, I’m pleased their are now avenues for those who care to do something about it.

The University of Oxford total diet replacement programmes also have had great recent success, but entail old fashioned willpower.
 




Weststander

Weststander

Well-known member
Aug 25, 2011
69,241
Withdean area
Professor Plum said:
Monster must be spending a fortune on marketing. I'm sure you've noticed that Fabian Hürzeler sits in front of 2 cans of the stuff at every single press conference.
Click to expand...

Noticed that at the Albion’s WSL manager press conference.

Weird world. Clamp down on gambling, then cans of Monster are pushed in viewers faces!
 


herecomesaregular

herecomesaregular

We're in the pipe, 5 by 5
Oct 27, 2008
4,649
Still in Brighton
Albion my Albion said:
I would say in the US it has already happened. Although after the jabs were introduced food companies started to complain there was a downturn in snack eating the the US. They actually started lobbying the government officials to do something to prevent this. Trump OTOH is doing everything he can to help the snack providers. Look at his body shape!
Click to expand...

When I was a kid in the 70s we never had "snacks" just 3 meals a day. I can't help but feel the snack, grazing culture has been our (my) downfall...
 


El Presidente

El Presidente

The ONLY Gay in Brighton
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Jul 5, 2003
40,000
Pattknull med Haksprut
Weststander said:
Including the drinks. It was Red Bull, now also Monster, cans of the stuff per day sometimes. The supermarkets have very well merchandised Monster coolers. I know younguns who get over being awake half the night, for uni lectures, by downing a can of Monster.

I think the epidemic is here already, we’ve followed the Yanks.

Best not mention vaping too :eek:.
Click to expand...

It would take more than a couple of cans of Monster to stay awake in one of my lectures.
 






The Clamp

The Clamp

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NSC Patron
Jan 11, 2016
26,182
West is BEST
In my line of work I see so many people reliant on energy drinks.

Water alone doesn’t keep me hydrated on a shift so I use the Dioralyte style rehydration powders mixed with water.

Luckily I find the Monster and Redbull style drinks absolutely revolting. So it’s no effort at all to swerve them .
 




S

Shropshire Seagull

Well-known member
Nov 5, 2004
8,785
Telford
Semaglutide is the underlying drug here, marketed under the names listed above. I'm a type 1 diabetic of some 35 years and all my blood vitals are decent, thanks to a cocktail of drugs, with insulin being my go-to life preserver.

As I passed 50 some years ago and lifestyle became more sedentary my weight crept up until my BMI got to 35. In May 2023 my diabetes specialist doctor mentioned this new drug, semaglutide, had just been approved by NICE for use in the UK, and explained how it worked (pep1 hormone). He also said it was in global short supply as non diabetic overweights were using it and weight loss clinics were even prescribing it to people with BMIs below 25.

So, I couldn't get the jab but have been taking daily in tablet form (Rybelsus) for almost 18 months now.

Pros, my insulin doses for carb intake and ratios are reduced, partly from eating less, but this drug definately makes my injected insulin work more efficiently (using less insulin and still maintaining acceptable blood/sugar control is massively beneficial to every type 1). My appetite is much reduced, now only a lite brunch, evening meal, and some TV snacking. So far, lost about 20lbs. Sad as I am, I weigh myself every Wednesday morning, have done since 2007, all recorded in excel. I now weigh less than I have done since 2013. My BMI is down to 30.

Cons, the tablet tastes awful as it slides down the throat. Must be taken on an empty stomach, so for 30 mins after I feel a bit odd in the tummy zone. Poo habits are varied, 3 times a day like water then nothing for 4 days interspersed with some normal movements. Nausea is the interesting one. Once a fortnight / 3 weeks or so I get that feeling (from saliva) that I'm going to be sick. After this random chunda I'm right as rain, most odd! Lots of my wardrobe is now too big and baggy for me (arguably a positive).

Happy to share more but I've wittered on long enough, don't want to be labelled a @Zeberdi
🥱
 




bhafc99

bhafc99

Well-known member
Oct 14, 2003
7,455
Dubai
I know someone taking Ozempic for diabetes (seems to be helping), and someone for weight loss (gave an initial loss, but didn’t make much difference long-term).

Personally I’d only go for these drugs as an absolute last resort. ‘Cheating’ or masking the body’s systems with pharmaceuticals is inherently unnatural, so should only be if it’s, well, almost critical really. Like your weight is impacting your health, longevity chances etc.

I know it’s super-patronising to hear, but ultimately a calorie deficit (using more calories through exercise than you consume through food) and a diet based around healthy foodstuffs is the best solution to losing weight in a controlled, natural way.
 




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