The only adds that are slightly disruptive are the video adds that spark up on their own with sound, such as on the Argus site. But apart from NSC and a couple of other sites, Add Block takes care of the rest.
Things may be changing though. I tried to buy a train ticket with Trainline the other day, it wouldn't let me complete the transaction until I turned Add Block off. It didn't tell me, I had to figure it out for myself. So if sites are not going to interact with you if you have Add Block turned on for their site.....Could get a tad annoying..........Enough to go down Goggles route?