Indeed. That said, using these drugs for a year to get from obese to a healthy weight is surely worth the risk, as long as you have a very clear plan to keep the weight off when the time comes to stop taking it. However, I suspect the majority of people doing it will balloon as soon as they stop taking it, and will end up going back on a maintenance dose, probably for life. Which is obviously what the Pharma companies want in the first place.Just be careful out there, people.
The long term effects are uncertain.
I have done some consulting on safety pharmacology, and I know what insufficient data looks like.
But of course I hope that all will end well.
The present signs are encouraging.
It's certainly the recommendation, that people use these treatments to try to re-educate themselves though there is the problem of many long-term obese people simply being wired in a different way eg an in-built problem with 'food noise' and a genetic under-production of the the GLP-1 hormone which, in 'normal' people, regulates satiety, and tells the brain to stop eating when the body has had enough food. Many obese people simply don't produce enough of this stuff. Weight-loss medication artificially increases GLP-1. So the risk is that stopping the treatment will just create the same issues again. Some people manage to deal with this better than others.
I'm not certain this is such a bad thing. Although I've been taking it less than 3 months, the benefits seem so impressive and far-reaching that I'm already thinking about staying on it for life. In fact, I've just switched provider to one who (at the moment at least) says it will continue to offer the treatments as a long-term maintenance dose. Most providers currently say they will stop supply once the user reaches a healthy BMI of around 22 or 23.
.Yes I just meant that we don't know what the long-term effects are yet. It might be risky business staying on them for life.It's certainly the recommendation, that people use these treatments to try to re-educate themselves though there is the problem of many long-term obese people simply being wired in a different way eg an in-built problem with 'food noise' and a genetic under-production of the the GLP-1 hormone which, in 'normal' people, regulates satiety, and tells the brain to stop eating when the body has had enough food. Many obese people simply don't produce enough of this stuff. Weight-loss medication artificially increases GLP-1. So the risk is that stopping the treatment will just create the same issues again. Some people manage to deal with this better than others.
I'm not certain this is such a bad thing. Although I've been taking it less than 3 months, the benefits seem so impressive and far-reaching that I'm already thinking about staying on it for life. In fact, I've just switched provider to one who (at the moment at least) says it will continue to offer the treatments as a long-term maintenance dose. Most providers currently say they will stop supply once the user reaches a healthy BMI of around 22 or 23.
Remember, a lot of people already take medications for life, for things like high blood pressure and T1 and T2 Diabetes, and plenty more conditions. Why not eating disorders, obesity, alcohol dependency, and all sorts of things for which Mounjaro is shown to be helpful? The latest research area is a reduction in the risk of dementia. If these are shown to be valid treatments for these issues, think of the dramatic reduction in the need for other more expensive options.
On the subject of cost, these drugs will continue to improve and become more convenient eg available in tablet form and perhaps just once a month rather than every week. And (as mentioned in the programme), patents will start to expire soon, making them much cheaper. Also, something I mentioned earlier, because I've stopped drinking alcohol and wasting money on takeaways and constant snacks, I have noticeably more money now in my bank account at the end of each month than previously, even taking into account the £30 or so per week it's currently costing me. The saving on Piglet Pies and lidless Coke alone has made quite a dent in my spending
Of course, it's true that we don't yet know the very long-term consequences of these medicines. But so far, so good.
Well, it’s funny you should say that. My shares in Greggs have dropped by about 30% in recent months. When I did a bit of googling to find out why, and whether they’d recover, I found more than one person opining that the growing use of weight-loss jabs were responsible! Seemed unlikely to me but certainly in the longer term we may well see consequences for the takeaway/fast food sector just as there’s apparently been a decline in city-centre eateries as more people work from home.
Blimey. Although it would make sense, as supposedly half a million people are currently taking them in the UK. And I imagine those half a million people are likely to be companies like Greggs' most loyal customers!
Quite.
I’ve been on them for three weeks, have lost three kilos, and am about to crack open an early Friday night beer. You just need some willpower to overcome it.
It’s not impossible to drink, especially towards the end of the MJ week when food suppression fades. And I’ve heard quite a few people on the Reddit groups saying they can still drink as normal at any time. I had 3 pints in Norwich, I think the only beer I’ve had in 3 months, and was fine. What’s killed me is wine. When I’ve had wine a couple of times I’ve had a really awful hangover. Overall I’ve found that I simply don’t want to drink. It’s not revulsion and I certainly don’t feel preachy about it. I’ve even been to the pub a few times and been happy not to drink. I’m actually really pleased I’ve stopped drinking and snacking. I’ve saved god knows how many hundreds of pounds and feel massively better. But then I did TBH drink too much previously and it was half the reason my diet was so shit. So I’m ok with the compromise.
I have a friend who has been on MJ for about 9 months and has had some great results on it. He says he has TRIPLED his alcohol intake and that a glass of wine in the evening helps him get through his meal.
Do you plan on keep taking it or cutting it and co trolling the weight you’re at without it?
Why on earth would he triple his drinking after embarking on a weight-loss plan? I’ve never heard anything like it.
Interesting....I'm 20% on the way I suspect....
