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[Misc] Weight loss jabs - Mounjaro, Wegovy etc.



Weststander

Weststander

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Aug 25, 2011
71,488
Withdean area
Professor Plum said:
Depends which expert you listen to! The default position was previously that you get down to your target weight having somehow reprogrammed yourself and then stop taking MJ. The problem with this is that this often doesn't work, and a lot of people found that old issues, behaviours, eating disorders returned, and they put weight back on. More recently the talk has been to reach your target weight and then titrate back down the doses to a 'maintenance level' which seems to have been a more successful approach so far. It's noticeable that among some providers, there's been more messaging recently about providing maintenance doses, unlike how things were just a few months ago. That's certainly my plan at the moment.

But quite honestly, there is no simple answer. We are still learning. Trouble is, everyone is different. People have different needs, issues, physiologies, and so it's hard to state what a one-size-fits-all might be. I'm convinced that these treatments are here to stay and that in years to come they will be much more widely available in more convenient forms eg a monthly pill, and they'll be regarded as pretty normal.

If I'm honest, I doubt if I'll read the book. I wasn't aware of it but have just read a couple of unflattering reviews including this one in the Guardian: https://www.theguardian.com/books/2024/may/01/magic-pill-by-johann-hari-review-weighing-in

It was written a year ago which is a long time in GLP-1 history. It's about Ozempic (Semaglutide) rather than Mounjaro (Tirzepatide), and appears to be very anecdotal. I've arrived at my own views after 5 months' experience plus a huge amount of (also anecdotal) reading from users on Reddit, Facebook, even Mumsnet etc. That amounts to as much research as I plan to do. I don't think there's some hidden truth out there that only dubious journos like Hari is party to. What we don't know, I fully admit, is what the very long term impact of these treatments might be but if anything, the news is getting better rather than worse. Mounjaro is now being used to treat a range of conditions ranging from ADHD, addictive and obsessive behaviour, high blood pressure, even sleep apnea. Call me a naive old fool if you wish, I don't mind, but honestly, so far I think it's a great drug with incredible potential. BUT (important caveat), again, everyone is different. Some people get side effects while others experience no food suppression or reduced 'food noise' at all. Apparently 10 or 15% might be in this category. So it's not for everybody.
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Whilst that’s unproven conjecture just now, going against the MHRA, what‘s not conjecture is that in the real world now a lot of folk have greatly reduced their odds of type 2 diabetes, some cancers, chronic inflammation and its many consequences, heart disease, chronic pancreatic issues.
 




Mr Banana

Mr Banana

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Aug 8, 2005
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Standing in the way of control
Sorry if this has been covered - I'm not bright enough to work out if there's a search function on threads - but these jabs aren't even viable as a last resort.

They cause muscle wastage, which is way riskier down the line and harder to resolve, especially as you get older, than the issues they are supposed to help with.

Hari is also a plagiarising chancer, unfortunately.
 


P

Professor Plum

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Jul 27, 2024
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Mr Banana said:
Sorry if this has been covered - I'm not bright enough to work out if there's a search function on threads - but these jabs aren't even viable as a last resort.

They cause muscle wastage, which is way riskier down the line and harder to resolve, especially as you get older, than the issues they are supposed to help with.

Hari is also a plagiarising chancer, unfortunately.
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The jabs don’t cause muscle wastage per se. Weight loss can indeed weaken muscles, regardless of how the weight is lost. The instructions issued with Mounjaro point this out and make it clear that users should increase exercise and do strength training to compensate. I’m not aware of losing muscle myself as my rate of loss is deliberately slow and steady but I have been doing some strength training and running as it happens, and my rowing machine keeps looking at me longingly. If you use MJ or similar, you have to do so responsibly and with a plan. It’s certainly not a ‘magic pill’, to use Hari’s ironic book title.
 




Couldn't Be Hyypia

Couldn't Be Hyypia

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Nov 12, 2006
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Mr Banana said:
Sorry if this has been covered - I'm not bright enough to work out if there's a search function on threads - but these jabs aren't even viable as a last resort.

They cause muscle wastage, which is way riskier down the line and harder to resolve, especially as you get older, than the issues they are supposed to help with.

Hari is also a plagiarising chancer, unfortunately.
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Interesting. Say more.
 






P

Professor Plum

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Solid at the back said:
Doesn't any weight loss cause a loss in muscle mass? To prevent that you'd need to do strength training, or even take creatine monohydrate?
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Strength training + additional protein intake. Usual recommended protein level is 1g per kg of body weight which is quite hard to do without protein shakes and the like. Steak and chicken breast are good sources too.

There are so many contradictory studies on this sort of thing, often with small numbers of participants, that you can always find one to back up your position (applies to me too). The uncontested fact is that any sort of sharp weight loss comes from fat loss and muscle loss. MJ and other GLP1 inhibitor treatments included. So with any weight loss regime it’s always recommended to exercise more and up the protein.
 


Jam The Man

Jam The Man

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Jul 5, 2003
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South East North Lancing
Jam The Man said:
Just found this thread.

After a lot of thought I started Mounjaro about a week and a half ago. I’m not massively overweight but due to a poor diet because of strange physical reactions I get from eating certain healthier foods, I felt I had to give something a try.

Exercise is difficult for me too, due to chronic tendinitis and plantar fasciitis in both feet.

I took the first jab 10 days ago and had a side-effect of an allergic reaction to my lip and wrists (hives etc) so I sought medical advice and was told to proceed with caution, and desist if any other reactions materialised.

After the second jab (last Weds) I had no reaction at all and no other side-effects.

I Genuinely don’t feel anywhere near as hungry as I used to so I guess it’s working, and I lost 6lbs in the first week.

The intention is to use it for three months max, with the hope that it gets me out of the habits I had of simply snacking and eating because I was bored.

If I can lose a reasonable bit of weight in that period of time it would’ve been worth the effort.
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Fourth and final jab from my first pen tonight, and staggeringly I've lost over stone so far at a rate of :

Week 1: 6lbs
Week 2: 6lbs
Week 3: 7lbs

Really quite surprised just how well it has worked for me and how cravings have been so minimalised.
 




HHGull

HHGull

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Dec 29, 2011
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Jam The Man said:
Fourth and final jab from my first pen tonight, and staggeringly I've lost over stone so far at a rate of :

Week 1: 6lbs
Week 2: 6lbs
Week 3: 7lbs

Really quite surprised just how well it has worked for me and how cravings have been so minimalised.
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One hell of a drug!
 


Harry Wilson's tackle

Harry Wilson's tackle

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Oct 8, 2003
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Couldn't Be Hyypia said:
Try reading Magic Pill by Johann Hari.

He's a journalist who has tried the injections and researched the pros and cons. He won't tell you what to conclude, but it is an eye opener.

I'd advise doing as much research as you can before you subject yourself to brain changing drugs.
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Hari is a shyster, plagiarist and serial liar.

en.wikipedia.org

Johann Hari - Wikipedia

en.wikipedia.org en.wikipedia.org
 


P

Professor Plum

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Jam The Man said:
Fourth and final jab from my first pen tonight, and staggeringly I've lost over stone so far at a rate of :

Week 1: 6lbs
Week 2: 6lbs
Week 3: 7lbs

Really quite surprised just how well it has worked for me and how cravings have been so minimalised.
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How’s the tendonitis and plantar fasciitis? I know from others that muscular issues can be greatly helped through losing weight.

Can I just offer a note of caution about very rapid weight loss? There was some earlier chat a few posts back about losing muscle, and the need to address this through protein and exercise. This is a genuine risk and I know you said you have trouble exercising. Aerobic exercise is obviously difficult or impossible with the pain of PF and tendonitis but if you can I’d recommend some home strength training. All you need is a kettlebell or a couple of dumbbells. Loads of guidance on YouTube.

Your results are amazing, well done, but do be careful. Gall bladder issues can occur with sudden weight loss which is one reason I’ve opted for the slow-but-steady approach. What you lost in 3 weeks took me 3.5 months! I’m very happy with about 1lb a week. Mind you, I’ve had minimal food suppression. I eat a near normal diet with the huge exception of booze and snacks, which Mounjaro has eliminated any desire for, and which I’m v happy about.

But congratulations on your remarkable progress. Just remember the protein for muscle loss, and need for high water intake. At least a couple of litres a day.
 




Jam The Man

Jam The Man

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Jul 5, 2003
8,284
South East North Lancing
Professor Plum said:
How’s the tendonitis and plantar fasciitis? I know from others that muscular issues can be greatly helped through losing weight.

Can I just offer a note of caution about very rapid weight loss? There was some earlier chat a few posts back about losing muscle, and the need to address this through protein and exercise. This is a genuine risk and I know you said you have trouble exercising. Aerobic exercise is obviously difficult or impossible with the pain of PF and tendonitis but if you can I’d recommend some home strength training. All you need is a kettlebell or a couple of dumbbells. Loads of guidance on YouTube.

Your results are amazing, well done, but do be careful. Gall bladder issues can occur with sudden weight loss which is one reason I’ve opted for the slow-but-steady approach. What you lost in 3 weeks took me 3.5 months! I’m very happy with about 1lb a week. Mind you, I’ve had minimal food suppression. I eat a near normal diet with the huge exception of booze and snacks, which Mounjaro has eliminated any desire for, and which I’m v happy about.

But congratulations on your remarkable progress. Just remember the protein for muscle loss, and need for high water intake. At least a couple of litres a day.
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Cheers for the considered response - plenty of food for thought there, so much appreciated.

It’s hard to tell re my plantar and tendons as I recently had a steroid injection which tends to mask that pain for a few months, but yes hopefully less weight will help matters.

I’ll certainly look on YT for a couple of exercise ideas thanks.

I do have a new spin bike and I started using that this week - oddly cycling never gives me increased foot pain like prolonged walking does.

My kidney area feels a little tender today though so I’m not sure if that’s related to the regime I’m on or if I’ve just pulled a muscle on the bike! Will keep an eye on it for sure.

I’m largely having protein as my main meal of the day so hopefully I’m on the right track, but I’m genuinely amazed at losing so much weight so rapidly. I’ve read that it’s not unheard of, but I don’t quite know why it’s happened as I don’t feel I’m exactly starving myself - the drug just seems to have taken hold I guess.

My intention was 3 months max to see how it goes but at this rate, 2 months might be enough to hit my target, and then I guess the hard work really starts to keep my new habits (no snacking, smaller portions) in place.

Certainly like yourself, the desires for the treats has pretty much disappeared.


My fluids intake is usually pretty good and I tend to easily get through at least 1.5 litres a day, although I guess I could up this.

Cheers again for the comments and insight.
 


C

ChickenDipper

Well-known member
Nov 8, 2024
367
Used mine for a month and worked very well suppressing hunger and lost over 2 stone in 3 months - half to 80% of that I’d attribute to the injection. It’s expensive though so not carried it on. Only annoying thing with it is it made me pretty tired / groggy when I managed a few pints and didn’t feel right. I like the odd binge every couple of weeks or so. And drink to get pissed. So not ideal. May go on a couple of months course soon again but don’t want to rely too heavily on it. Have kept weight off well from new habits and healthier eating.
 


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