I think that there are two key questions
Can gross play in one of the deeper midfield roles in place of Propper or Stephens. If this was the case Locadia could play with Murray up front. Id say this option seems unlikely.
We must play Izquierdo who has been on fire. Can we play Izquierdo and Locadia together on the wings. Could one of them (Locadia) play right wing?
If neither is an option then I expect the usual starting line up with March on the right wing. Locadia could come on for Gross or Izquierdo and Ulloa for Murray
That was then this is now.as demonstrated by our record with/without him over the last couple of years. .
PS: It seems that Locadia is meant to run around a lot and seems the best choice.