Certainly not a mid-life crisis but I changed my career path mid 20s. Was really enjoying working in hotels and considered training as a chef. Instead I moved to IT / Telecoms as that's what I was qualified in. I changed because I wanted to earn good money and get a mortgage. Until January this year I occasionally regretted not re-training. Now all I want to do is cut my hours and look towards semi-retirement - don't hate my job / industry but just not interested in learning anything new as a career. With my hindsight hat on I'd say go for it - whatever 'it' maybe - don't look backwards with regret for not doing it.