[Misc] Weight loss jabs - Mounjaro, Wegovy etc.

wehatepalace · Jan 14, 2025

Coldeanseagull said:
I'm now on 7.5g, have been for last couple of months...which seems to work best for me. On day two after the injection, I get 'eggy breath'. Also a little bit of indigestion and just a tad constipated. I've now lost 5st.
I've gone down from OMG to oi chubs. My clothes are too big now, so forking out for a new wardrobe as well as injections!
1/2st more and I think it'll be maintenance time.
My portion sizes have gone down with a lot more healthy stuff being consumed and I don't tend to 'graze' in the evenings now, if I do, it's fruit. I feel and look so much better with more energy and I can see my feet again!

Congratulations!
Im now down 3 stone, people are now commenting on how much I’ve lost, clothes are also looking too big and don’t fit very well.
I’m week 1 into my 10mg dose so I’ve lost just under a stone per month

Side effects wise, indigestion, constipation and sulphur burps are the worst I’ve had along side some stomach cramps, these only really started towards the end of my 7.5mg dose

The best thing for me is I don’t really get hungry any more, I manage on an apple for breakfast a banana for lunch and a normal meal in the evening,, but it’s also teaching me how to live a healthier lifestyle, I’ve given up the booze and drink so much more water everyday.

This drug really has started to change my life, I’d like to lose another 2-3 stone ideally and for the first time ever I think I’ll achieve my goal !

Professor Plum · Jan 14, 2025

Weststander said:
@Professor Plum the progress you mention in post #185 may be fine. Average results are 15% weight loss after 68 weeks.
https://www.bbc.com/future/article/20240521-what-happens-when-you-stop-taking-ozempic

Your starting weight doesn’t stand out as very high. Perhaps others started out in a position, where initial progress can be fast.

I’m not complaining about my rate of loss. In fact I prefer slow and steady over rapid. Around 1 to 1.5 lbs a week is a healthy rate and more likely to be sustainable in the long run.

My weight has drifted all over the place between roughly 240 and 215 lbs over 30+ years. I can lose weight very quickly and put it back even quicker. Mounjaro has allowed me to have a relatively normal relationship with food at last. No 'food noise', no binge eating, no alcohol issues. Just something similar to a normal person's normal appetite. It feels hugely liberating.

Professor Plum · Jan 14, 2025

wehatepalace said:
Congratulations!
Im now down 3 stone, people are now commenting on how much I’ve lost, clothes are also looking too big and don’t fit very well.
I’m week 1 into my 10mg dose so I’ve lost just under a stone per month

Side effects wise, indigestion, constipation and sulphur burps are the worst I’ve had along side some stomach cramps, these only really started towards the end of my 7.5mg dose

The best thing for me is I don’t really get hungry any more, I manage on an apple for breakfast a banana for lunch and a normal meal in the evening,, but it’s also teaching me how to live a healthier lifestyle, I’ve given up the booze and drink so much more water everyday.

This drug really has started to change my life, I’d like to lose another 2-3 stone ideally and for the first time ever I think I’ll achieve my goal !

That’s brilliant, well done. Sounds like you’re well in control.

I’ve been on 5mg for 2 months and am going to do another month on it. After that I’ll think about 7.5mg. Unlike you, I do still get hungry, except for a day or two after a jab, which may be a sign that I should go up a dose. I’m deliberately having a fairly normal breakfast — toast with cereal and fruit or eggs or even, once a week, a small fry-up. Nothing much for lunch then a normal evening meal, though usually a smaller portion than previously. It’s a deliberate strategy. I’m just trying to eat normally to try to make it easier to come off MJ eventually. The gamechanger for me has been a loss of interest in booze and snacks.

Good luck!

ChickenDipper · Jan 14, 2025

Coldeanseagull said:
I'm now on 7.5g, have been for last couple of months...which seems to work best for me. On day two after the injection, I get 'eggy breath'. Also a little bit of indigestion and just a tad constipated. I've now lost 5st.
I've gone down from OMG to oi chubs. My clothes are too big now, so forking out for a new wardrobe as well as injections!
1/2st more and I think it'll be maintenance time.
My portion sizes have gone down with a lot more healthy stuff being consumed and I don't tend to 'graze' in the evenings now, if I do, it's fruit. I feel and look so much better with more energy and I can see my feet again!

Brilliant stuff. How many months have you been on it and is your plan to come off it soon and just maintain without it?

Also, can I ask what your weight was to start? PM if you’d rather not put on board!

wehatepalace said:
Congratulations!
Im now down 3 stone, people are now commenting on how much I’ve lost, clothes are also looking too big and don’t fit very well.
I’m week 1 into my 10mg dose so I’ve lost just under a stone per month

Side effects wise, indigestion, constipation and sulphur burps are the worst I’ve had along side some stomach cramps, these only really started towards the end of my 7.5mg dose

The best thing for me is I don’t really get hungry any more, I manage on an apple for breakfast a banana for lunch and a normal meal in the evening,, but it’s also teaching me how to live a healthier lifestyle, I’ve given up the booze and drink so much more water everyday.

This drug really has started to change my life, I’d like to lose another 2-3 stone ideally and for the first time ever I think I’ll achieve my goal !

Well done too! Can I ask, what your plan is long term too pls in terms of coming off it? I may do 6 months then stop and maintain but worried if I get to the max dose I’ll end up relying on it too much..!

Also what was your start weight if you don’t mind sayin?

wehatepalace · Jan 15, 2025

ChickenDipper said:
Brilliant stuff. How many months have you been on it and is your plan to come off it soon and just maintain without it?

Also, can I ask what your weight was to start? PM if you’d rather not put on board!

Well done too! Can I ask, what your plan is long term too pls in terms of coming off it? I may do 6 months then stop and maintain but worried if I get to the max dose I’ll end up relying on it too much..!

Also what was your start weight if you don’t mind sayin?

I’ve always been heavy, not going to deny that, I played semi pro rugby and my playing weight was always around 19 stone but I was always muscular with it, when I retired I naively thought I could carry on eating and drinking like I did, then middle age struck and I was disgusted that I’d put on 4 stone, leaving me around the 23st area, that’s when I knew I had to sort myself out!

Tried dieting but I have zero will power and with dodgy knees and back alongside various other injuries from a 30 year rugby career, I found exercising like I used to extremely difficult.

I deliberated whether to start on MJ for a fair few months as it felt like cheating but I’m so glad I did, I’ve just about broken the 20st mark now and ideally I’d like to get down to around 17 stone by the time I’m 50 in September, I’m 6’5” so 17 stone would be a comfortable weight for me.

Will I carry on with a maintenance dose ? I’m not sure, I’d hope by then I would be in a much better place to be able to control my weight and got rid of the bad habits I’d fallen in to, but if I felt the need to carry on with a low dose, I really wouldn’t think twice about it.

Shropshire Seagull · Jan 15, 2025

Been on semaglutide daily tablets (Rybelsus) for 20 months now. When my diabetes doctor started me on it there was a global shortage of semaglutide in injection form because all the private weight-loss clinics were buying it up for their wealthy clients (real wives of Skinnyville).

Probably losing, on average, a couple of pounds a month (rate had slowed in last six months).

Had my 4th or 5th random chunda yesterday. Just finished a bowl of soup and a bread roll for brunch about noon. Back to kitchen I suddenly got that tell-tale taste in my saliva that I was going to be sick. 30 seconds later my head was down the pan ... 5 mins later and right as rain again.

Last time it happened was around August out in the garden, no time to get to the toilet so the flowers copped it.

It's random and very definately semaglutide is the cause. Back end swings from water to constipation, but, for me, the positives still outweigh the negatives, especially for my blood-glucose control, which is what semaglutide was originally invented for.

BrickTamland · Jan 15, 2025

Scarry Black Mirror stuff

Professor Plum · Jan 15, 2025

wehatepalace said:
I’ve always been heavy, not going to deny that, I played semi pro rugby and my playing weight was always around 19 stone but I was always muscular with it, when I retired I naively thought I could carry on eating and drinking like I did, then middle age struck and I was disgusted that I’d put on 4 stone, leaving me around the 23st area, that’s when I knew I had to sort myself out!

Tried dieting but I have zero will power and with dodgy knees and back alongside various other injuries from a 30 year rugby career, I found exercising like I used to extremely difficult.

I deliberated whether to start on MJ for a fair few months as it felt like cheating but I’m so glad I did, I’ve just about broken the 20st mark now and ideally I’d like to get down to around 17 stone by the time I’m 50 in September, I’m 6’5” so 17 stone would be a comfortable weight for me.

Will I carry on with a maintenance dose ? I’m not sure, I’d hope by then I would be in a much better place to be able to control my weight and got rid of the bad habits I’d fallen in to, but if I felt the need to carry on with a low dose, I really wouldn’t think twice about it.

MJ isn’t cheating! It just enables you to produce GLP-1 like most normal people.

Once I get down to my target weight of about 175 lbs I’ll have no qualms about continuing on a maintenance dose. Presuming there are no sudden bad side effects. Research is flying along with the prospect of once-a-month jabs or pills on the horizon. These medications will become even more mainstream than they are now as they will save the NHS so much money. They will also become cheaper. Not that I complain about the cost. The money I save on booze and crappy takeaways and snacks pays for MJ three times over. I have more money left over in my bank account each month now than I have had for years.

wehatepalace · Jan 15, 2025

Professor Plum said:
MJ isn’t cheating! It just enables you to produce GLP-1 like most normal people.

Once I get down to my target weight of about 175 lbs I’ll have no qualms about continuing on a maintenance dose. Presuming there are no sudden bad side effects. Research is flying along with the prospect of once-a-month jabs or pills on the horizon. These medications will become even more mainstream than they are now as they will save the NHS so much money. They will also become cheaper. Not that I complain about the cost. The money I save on booze and crappy takeaways and snacks pays for MJ three times over. I have more money left over in my bank account each month now than I have had for years.

No I know that now, but at the start I did think it was, once I’d researched it and understood how it worked I appreciated it for what it is, an aid to weight loss, you still need to do the work !

Weststander · Thursday at 4:44 PM

Excellent listen, including success stories and otherwise.

You and Yours - Call You & Yours: Are you on weight loss drugs? - BBC Sounds

Call You & Yours: Are you on weight-loss drugs; are they working for you?

www.bbc.co.uk

Professor Plum · Thursday at 9:00 PM

Weststander said:
Excellent listen, including success stories and otherwise.

You and Yours - Call You & Yours: Are you on weight loss drugs? - BBC Sounds

Call You & Yours: Are you on weight-loss drugs; are they working for you?

www.bbc.co.uk

Thanks, I’ll listen with interest.

I also found this recent news very interesting, and seems to confirm my feeling that Mounjaro (etc) has many additional peripheral benefits. I breathe much better at night for instance and my wife tells me I’ve been snoring less. Great implications for sleep apnea and related conditions. Good for reducing alcohol intake and drug addiction too.

Weight-loss jabs linked to reduced risk of 42 conditions including dementia

Psychotic disorders also among conditions found less likely when people with diabetes took medications found in jabs

www.theguardian.com

Weststander · Thursday at 9:32 PM

Professor Plum said:
Thanks, I’ll listen with interest.

I also found this recent news very interesting, and seems to confirm my feeling that Mounjaro (etc) has many additional peripheral benefits. I breathe much better at night for instance and my wife tells me I’ve been snoring less. Great implications for sleep apnea and related conditions. Good for reducing alcohol intake and drug addiction too.

Weight-loss jabs linked to reduced risk of 42 conditions including dementia

Psychotic disorders also among conditions found less likely when people with diabetes took medications found in jabs

www.theguardian.com

In the R4 show a bloke said he was able to stop meds eg one for gout. Until then he thought taking them was for life.

Harry Wilson's tackle · Thursday at 10:28 PM

Just be careful out there, people.
The long term effects are uncertain.

I have done some consulting on safety pharmacology, and I know what insufficient data looks like.

But of course I hope that all will end well.
The present signs are encouraging. :thumbsup:

Harry Wilson's tackle · Thursday at 10:29 PM

Weststander said:
In the R4 show a bloke said he was able to stop meds eg one for gout. Until then he thought taking them was for life.

My ex wife's mum was cured of ankylosing spondylitis by evening primrose oil.
Beware anecdotes....

Weststander · Thursday at 10:36 PM

Harry Wilson's tackle said:
My ex wife's mum was cured of ankylosing spondylitis by evening primrose oil.
Beware anecdotes....

The benefits of losing a shedload of weight/fat are known, going by genuine cancer experts and dementia experts. In terms of risk factors. Then obviously reversing type 2 diabetes.

Harry Wilson's tackle · Friday at 1:23 AM

Weststander said:
The benefits of losing a shedload of weight/fat are known, going by genuine cancer experts and dementia experts. In terms of risk factors. Then obviously reversing type 2 diabetes.

I can't help worrying that if you are overweight then losing the weight this way may be not completely dissimilar to losing weight by cutting off one of your legs. If you get my drift.

In my research lab, I once tried to prevent oedema in perfused hearts by adding albumen to the perfusate.
The oedema was prevented, but the water was removed primarily from the extracellular space, and the hearts stopped beating.
They looked great though.

Shropshire Seagull · Friday at 11:48 AM

Weststander said:
Excellent listen, including success stories and otherwise.

You and Yours - Call You & Yours: Are you on weight loss drugs? - BBC Sounds

Call You & Yours: Are you on weight-loss drugs; are they working for you?

www.bbc.co.uk

Agreed, an excellent listen, I can fully resonate with the "food noise" and associated temptation.

Semaglutide has definitely quietened this down in my case.
What I hadn't been aware of were cases of malnutrition. If you're gonna eat less, it's important you're eating the right food.
I've recently done a blood test and GP has put me on 6mg (high) daily Folic Acid dose for 6 weeks as I'm iron deficient.

So, my takeaway (pardon the pun) is to be mindful of quality of what you eat when your quantity is reduced.

Professor Plum · Friday at 12:08 PM

Harry Wilson's tackle said:
Just be careful out there, people.
The long term effects are uncertain.

I have done some consulting on safety pharmacology, and I know what insufficient data looks like.

But of course I hope that all will end well.
The present signs are encouraging.

Shropshire Seagull said:
Agreed, an excellent listen, I can fully resonate with the "food noise" and associated temptation.

Semaglutide has definitely quietened this down in my case.
What I hadn't been aware of were cases of malnutrition. If you're gonna eat less, it's important you're eating the right food.
I've recently done a blood test and GP has put me on 6mg (high) daily Folic Acid dose for 6 weeks as I'm iron deficient.

So, my takeaway (pardon the pun) is to be mindful of quality of what you eat when your quantity is reduced.

I listened as well and found it quite heartening. Thanks for the link. Though I suspect the show's producer was tearing her hair out hoping to get more negative experiences to balance things out! I still find there’s some naivety about the medications but overall, I’m impressed with the maturity of users and the seriousness they apply to their 'journey' (not a word I like but frequently used in the MJ community). If these people are anything to go by, not many are thinking of it as a quick fix but as the foundation for a new way of living. Which is pretty much my approach too.

stewardxxx · Friday at 12:31 PM

Quick update from me on my journey with Mounjaro:

Since 22nd Sept I have lost a shade over 3 stone. wearing 32inch waist trousers and have gone from XXL shirts to L.
I had my first blood test results since starting and my HbA1c % has dropped from 6.9 to 5.4 - I am no expert in this but googling suggests that is the level found in "normal" people. Cholesterol:HDL ratio has gone from 4.4 to 2.6 and everything else is well within range.

I know that it is not solely Mounjaro that has done this but I will definitely credit it with 66.7% of it. I am still only on th 5mg injections so keen to see what the outcome of my blood test review will be next week!

Change at Barnham · Friday at 1:10 PM

Weststander said:
Excellent listen, including success stories and otherwise.

You and Yours - Call You & Yours: Are you on weight loss drugs? - BBC Sounds

Call You & Yours: Are you on weight-loss drugs; are they working for you?

www.bbc.co.uk

Thanks for sharing, I've just had a listen.
My take from the programme is that the drugs are successful in helping people to lose weight, and they also provide big benefits of helping reduce secondary health problems and also improve mental well-being.

The downside seems to be the medical experts saying that once people stop taking the drugs then the weight will return. Therefore it requires a long term maintenance dose.

However, as someone who struggles with being overweight (6ft/16'7") I think the mental health benefits of being lighter may well be worth it.
I'll follow the thread and the news articles to try and learn a bit more.

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[Misc] Weight loss jabs - Mounjaro, Wegovy etc.

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