Get a nasty virus e.g. Norovirus a few days before you plan on getting hammered, your immune system gets into full swing, cleans up your body and is ready to fight off the alcohol thus avoiding any hangover. This worked for me just before Christmas although on the down side you have to be ill for a couple of days and chuck your guts up until there is nothing left, I guess it's like getting the hangover out of the way before the drinking. Swings and roundabouts.