Usually stay near Times Square as very central and easy to get anywhere (and close to the office). I like the Hilton Times Square - not noisy as hotel rooms are from about 23rd floor up. The Iriquois is OK but limited facilities and small rooms. The Langham is expensive but the rooms are absolutely huge. The Hyatt Times Square decent value with again decent sized rooms. The Hilton on Av of the Americas is very large with a great gym. I don't like the Barclay (Intercontinental) much - very impersonal and some rooms need refreshing. NY prices are generally eye-watering so have a good look around and check them out on TripAdvisor, mist will have hundreds of reviews so you can get a reliable view.